IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2.? IL-15 exerts its biological activities primarily on T cells.? It is also essential in the development, survival and activation of NK cells.? Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I.? Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells.? Recombinant Rat IL-15 is a 13.5 kDa protein consisting of 115 amino acid residues.
Source: E.coli
Synonyms: IL-T
AA Sequence: MNWIDVRYDL EKIESLIQFI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VIESGCKECE ELEERNFTEF LQSFIHIVQM FINTS
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of murine CTLL-2 cells is?≤ 10 ng/ml, corresponding to a specific activity of?≥ 1 x 105 units/mg.
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