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A Tankyrase (TNKS) inhibitor (IC= 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation ofcatenin degradation and stabilization of axin. Inhibits proliferation of the-catenin-dependent colon carcinoma cell line DLD-1.

Additional Information

Synonyms	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
Product #	X-2484
CAS #	284028-89-3
Chemical Name	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
Formula	C14H11F3N2OS
MW	312.31
Appearance	White Solid
Purity	98% by HPLC
Solubility	DMSO (50 mM)
Melting Point	207.14 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A potent inhibitor of beta-catenin, TNKS1, and TNKS2.XAV939 inhibits colony formation of APC-deficient colorectal cancer cells

Additional Information

MDL Number	MFCD16879017
ChemACX	X1833197-6
InChI	InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
SMILES	c1cc(ccc1c2[nH]c(=O)c3c(n2)CCSC3)C(F)(F)F