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上海拜力生物科技公司
Tel:400-968-7988    021-33779008
BRD9757,HDAC6Inhibitor
品牌:Xcessbio
貨號:M60117-2
規格:10 mM DMSO (1.573 mL)
貨期:

BRD9757,HDAC6Inhibitor

商品詳情 參考文獻 相關資料
Product Information
Molecular Weight: 127.14
Formula: C6H9NO2
Purity: ≥98%
CAS#: 1423058-85-8
Solubility: DMSO up to 100 mM
Chemical Name: N-hydroxycyclopent-1-enecarboxamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. It has >20-fold selectivity for class I and > 400-fold selectivity for class II HDACs tested. BRD9757 is absence of a surface-binding motif. It demonstrates that high selectivity and potent inhibition of HDAC6 can be achieved through careful choice of linker element only. BRD9757 can be used as a useful tool for probing the biological functions and relevance of the different HDAC isoforms, and serves as a basis for new selective inhibitors of other HDAC isoforms.


How to Use:

In vitro:? BRD9757 was suggested to be used at 10 μM final concentration in vitro and in cellular assays.

In vivo: ?n/a


Reference:

  1. 1. Wagner FF, et al. Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif. (2013) J Med Chem. 56 (4), 1772–1776.




Products are for research use only. Not for human use.

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