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LMK235 is a potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor ?(IC₅₀?~11.9 nM and 4.22 nM respectively). ?It also has inhibitory activities against HDAC 6, 1, 11, 2, and 8 with IC_50?for 55.7, 320, 852, 881, and 1278 nM, respectively. LMK235 exhibits cytotoxity against chemo-resistant cancer cell lines in human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC₅₀?~0.49 and 0.32 μM respectively).?

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How to Use:?

• In vitro:? LMK235 was used at 1 μM final concentration in vitro and in cellular assays.
• In vivo:?n/a

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Reference:

• 1. Marek L, et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. (2013) J Med Chem. 56(2):427-36.?

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Products are for research use only. Not for human use.