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Anti-FAM111A (C20) Antibody

品牌：Antibodies

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規格：50μl

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Anti-FAM111A (C20) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-FAM111A (C20) Antibody See all FAM111A primary antibodies
Description:	Rabbit polyclonal antibody to FAM111A (C20)
Specificity:	FAM111A (C20) pAb detects endogenous levels of FAM111A protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human FAM111A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 70 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Target

Function:	Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis (PubMed:24561620). May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction (PubMed:23093934).
Involvement in Disease:	Kenny-Caffey syndrome 2: A disorder characterized by impaired skeletal development with small and dense bones, short stature, and primary hypoparathyroidism with hypocalcemia. Clinical features include cortical thickening and medullary stenosis of the tubular bones, delayed closure of fontanels, defective dentition, small eyes with hypermetropia, and frontal bossing with a triangular face. Gracile bone dysplasia: A perinatally lethal condition characterized by narrowing of the medullary cavity of the long bones and of the skull, gracile bones with thin diaphyses, premature closure of basal cranial sutures, and microphthalmia. Most affected individuals who survive beyond the perinatal period develop hypocalcemia with low parathyroid hormone levels.
Sequence Similarities:	Belongs to the FAM111 family.
Cellular Location:	Nucleus. Cytoplasm. Mainly localizes to nucleus: colocalizes with PCNA on replication sites.
Database Links:	Entrez Gene: 63901?Human Entrez Gene: 107373?Mouse Entrez Gene: 499322?Rat Omim: 615292?Human SwissProt: Q96PZ2?Human SwissProt: Q9D2L9?Mouse Unigene: 150651?Human Unigene: 1643?Mouse Unigene: 112856?Rat
Synonyms:	FAM111A Antibody Family with sequence similarity 111 member A Antibody GCLEB Antibody Hypothetical protein LOC63901 Antibody KCS2 Antibody KIAA1895 Antibody Protein FAM111A Antibody RGD1560913 Antibody
Information:	Target information shown above is from the UniProt Consortium.