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Anti-Cox-2 (T594) Antibody

品牌：Antibodies

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規格：50μl

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Anti-Cox-2 (T594) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-Cox-2 (T594) Antibody See all Cox2 primary antibodies
Description:	Rabbit polyclonal antibody to Cox-2 (T594)
Specificity:	Cox2 (T594) pAb detects endogenous levels of Cox2 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids C-terminus of Human Cox-2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 74 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Sequence Similarities:	Belongs to the prostaglandin G/H synthase family.
Post-Translational Modification:	S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.
Cellular Location:	Microsome membrane. Endoplasmic reticulum membrane.
Database Links:	Entrez Gene: 5743?Human Entrez Gene: 19225?Mouse Omim: 600262?Human SwissProt: P35354?Human SwissProt: Q05769?Mouse Unigene: 196384?Human Unigene: 292547?Mouse
Synonyms:	COX 2 Antibody COX-2 Antibody COX2 Antibody Cyclooxygenase 2 Antibody Cyclooxygenase 2b Antibody Cyclooxygenase-2 Antibody Glucocorticoid-regulated inframmatory prostagandin G/H synthase Antibody GRIPGHS Antibody hCox 2 Antibody PGG/HS Antibody PGH synthase 2 Antibody PGH2_HUMAN Antibody PGHS 2 Antibody PGHS-2 Antibody PGHS2 Antibody PHS 2 Antibody PHS II Antibody Prostaglandin endoperoxide synthase 2 Antibody Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Antibody Prostaglandin G/H synthase 2 Antibody Prostaglandin G/H synthase and cyclooxygenase Antibody Prostaglandin H2 synthase 2 Antibody Prostaglandin-endoperoxide synthase 2 Antibody PTGS2 Antibody
Information:	Target information shown above is from the UniProt Consortium.