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≥ 95% by SDS PAGE

Phosphate Buffered Saline

Baboon, Cynomolgus Monkey

≤ 30 days 2°C to 8°C
> 30 days ≤ –20°C

For Research Use Only. Not for use in Diagnostic Procedures

Factor H is a fluid phase complement regulatory protein consisting of a single peptide chain of 20 short consensus repeat segments or CCP’s with a molecular weight of approximately 155 KD. 1 Factor H regulates the alternative pathway of the complement system by modifying activity of the “feedback loop.” It does this in three ways. First, it is a co-factor for the serine protease Factor I, which cleaves C3b to iC3b. iC3b has no hemolytic or amplification function, but may be bound by complement receptors. Second, Factor H prevents the formation of and accelerates the disassociation of the alternative pathway C3 convertase, C3bBb from cell surfaces. Finally, Factor H binds to polyanions on host cell surfaces and tissue matrices, such as basement membranes, blocking deposition of C3b. This later activity is leveraged by many pathogens as a mode of complement evasion. 2

This monoclonal antibody was raised against purified human Factor H. Studies have shown that this antibody functionally inhibits Factor H.

Quidel's Factor H monoclonal antibody has been used in a variety of experimental techniques including EIA and Western Blot

 Applications of this antibody have been evaluated by various research facilities, and include EIA, 5 Western Blot, 4 and FACS. Studies have shown that this antibody functionally inhibits Factor H and can be used to deplete Factor H from Human Serum. 6,7